BIOINFORMATICS SEMINAR SERIES
https://bioinformatics.udel.edu/seminar
Gene regulation by alternative polyadenylation: mechanisms and consequences
Bin Tian, PhD
Professor and Program Co-Leader
Genome Regulation and Cell Signaling Program
The Wistar Institute
Philadelphia, USA
Abstract: Most mammalian genes display alternative polyadenylation (APA), through which multiple mRNA isoforms are produced due to the choice of 3′ end cleavage and polyadenylation site (PAS). APA is highly cell type-specific and is dynamically regulated in cell differentiation and development. Dysregulation of APA has been reported in a growing number of human diseases. In this talk I will present our current understanding of molecular mechanisms that impact APA in different cell contexts. I will particularly discuss our recent work on cleavage factor I (CFI) proteins which are master regulators of APA in 3′ untranslated region and play important roles in cell metabolism and drug tolerance of melanoma cells.
Short Bio: Dr. Tian received his B.S. degree in biochemistry from East China University of Science and Technology and his Ph.D. degree in molecular biology from Rutgers Biomedical and Health Sciences (formerly UMDNJ). He was a postdoctoral fellow in bioinformatics and genomics at Johnson & Johnson Pharmaceutical Research & Development in La Jolla, California. In 2003, he established his research group at Rutgers New Jersey Medical School, where he rose through the ranks and became a tenured professor in 2014. Dr. Tian joined The Wistar Institute in 2020 and is currently Co-Leader of the Genome Regulation and Cell Signaling Program. His research has centered on RNA biology.
