BIOINFORMATICS SEMINAR SERIES
https://bioinformatics.udel.edu/seminar
Identification of the substrates and targets of ADAM9 in colorectal cancer using multi-omics integration
Neha Sindhu
Ph.D. candidate in Bioinformatics Data Sciences
Center for Bioinformatics and Computational Biology
University of Delaware
Abstract; ADAM9 is a cell-surface protease whose elevated expression is implicated in several solid tumors and other pathologies, including inflammation and neurodegenerative diseases. Conversely, the loss of ADAM9 has little adverse effect except for eventual retinal degeneration in humans and mice (Goldstein et al., 2010). This makes ADAM9 a good candidate as a tumor drug target. Finding the substrates and targets of ADAM9 can provide more insights into the proteolytic function of ADAM9, which in turn can be targeted for drug development. This proposed research aims to accomplish this by utilizing O2PLS and OnPLS to compare the integrated transcriptome, cellular proteome, and secretome of HCT116 colon cancer cells with and without ADAM9 knockdown. This integrated multi-omics dataset will be used to identify potential substrates and targets of ADAM9, which can be further validated experimentally
Bio; Neha is a Ph.D. candidate in Bioinformatics Data Sciences at the Center for Bioinformatics and Computational Biology at UD. She works with Dr. Shuo Wei, Associate Professor in the Department of Biological Sciences. Neha did an integrated BS-MS program at the Indian Institute of Science Education and Research (IISER), Thiruvananthapuram with a major in mathematics. Her primary research involves the use of bioinformatics methods, specifically multi-omics and single-cell omics to understand the molecular mechanisms of solid tumors and embryonic development.
