CBCB Seminar

April 1, 2024 3:30 PM

Ammon-Pinizzotto Biopharmaceutical Innovation (BPI) Building
Conference Room 140

We are not alone: the role of the intestinal microbiome in the setting of sepsis

Nathan Klingensmith, MD

Assistant Professor
Division of Traumatology, University of Pennsylvania

Abstract:  Sepsis resulting from a dysregulated immune response to infection. However, our understanding of the immune system can no longer be viewed in isolation. The microbiome shapes our immune responses, not only to infections, but to everyday exposures. We will discuss how the intestinal microbiome plays a key role in how our body reacts to stimuli and can help (or hurt) our responses to infection, potentially resulting in the development sepsis.

Bio:  Nathan Klingensmith is an Assistant Professor of Surgery at the University of Pennsylvania in the Division of Traumatology, Surgical Critical Care, and Emergency Surgery Services. He received is Medical Degree from West Virginia University. He completed is General Surgery Residency at Emory University followed by a fellowship in Trauma Surgery and Surgical Critical Care at Emory and Grady Memorial Hospital, all in Atlanta, GA. During his training, he was a NIH T32 post-doctoral research fellow investigating the role of the intestinal epithelium, immune system, and the microbiome and how these systems are dysregulated in sepsis. In addition to taking care of patients at Penn, he has a basic science research lab continuing his investigation of the role of the intestinal microbiome in immune tolerance and training at homeostasis and how this balance changes during sepsis.