Staff Scientist, NCBI, National Library of Medicine, NIH, MD
This lecture is a general overview of the human influenza virus evolution and epidemiology. It will discuss the concepts of antigenic drift and antigenic shift, pandemics vs seasonal epidemics and antigenic vs genetic evolution in influenza A. An overview of influenza epidemic history in human population will be given. It will also discuss major human influenza virus subtypes (H1N1 and H3N2) and the longevity of H3N2 subtype in human population and continuing occurrence of severe H3N2-dominated seasonal epidemics which distinguishes it from other subtypes. Influenza seasonal vaccine decision process and challenges will be briefly summarized. At the end, it will include a brief overview of the NCBI Influenza virus database.