SysCLFT (Systems tool for Cleft Lip/palate gene discovery)
Future: Developing a comprehensive version of SysCLFT
Future versions of SysCLFT will incorporate extensive microarray data generated from newly generated or published datasets. In combination with other genome-wide studies e.g. NIH-supported FaceBase initiative [https://www.facebase.org/], network of validated gene regulatory relationships, and effective use of bioinformatics algorithms, newer versions of SysCLFT will be more comprehensive and lead to the understanding of orofacial development and pathogenesis, as well as for the highly efficient identification of disease associated genes in genomic intervals in human patients. In collaboration with Dr. Joshua Ho (Victor Chang Institute, Sydney, Australia), we are currently assembling a curated evidence-based gene regulatory network for craniofacial morphogenesis (Fig. 1), which we plan to integrate into future versions of SysCLFT.