Data integration and evidence tracking in biomedical knowledgebases such as GlyGen and OncoMX
Professor, Biochemistry and Molecular Medicine and Co-Director of The McCormick Genomic Proteomic Center at The George Washington University, DC
October 24, 2022 | 3:30 PM
Ammon-Pinizzotto Biopharmaceutical Innovation (BPI) Building
Conference Room 140
Technological advancements such as high-throughput sequencing have revolutionized life sciences research, resulting in an –omics data boom that has provided more depth and breadth than ever before. Downstream, data generated by these technologies require complex computational analyses. Once the data is analyzed, annotations are generated through a combination of manual and automated methods. These annotations form the basis of many knowledgebases such as GlyGen, OncoMX, and UniProt. The ability to access and repeat manual and computational curation and data integration pipelines involved in generating these annotations are quite difficult and often open to interpretation. This talk will provide an overview of our approaches on how BioCompute Objects (BCO, https://biocomputeobject.org/) are being used to track data and annotations in the GlyGen knowledgebase (glygen.org). How BCO use can also help track the evolution of bioinformatics analysis over time and promote best practices for data analysis and biocuration will also be discussed.
As a Professor of Biochemistry and Molecular Medicine and Co-Director of The McCormick Genomic & Proteomic Center at The George Washington University (GW) Dr. Mazumder works closely with national and international collaborators in developing molecular biology resources. His research focus is on developing novel methods for data-to-knowledge discovery and community driven bioinformatics projects such as the BioCompute initiative, GlyGen knowledgebase, and the High Performance Integrated Virtual Environment (HIVE). He has experience in scientific management, bioinformatics infrastructure building, and through NCI, NSF, NIAID, NIH Common Fund, pharmaceutical, non-profit, and FDA funding he has been involved in bioinformatics research associated with cancer biology, glycobiology, microbiology, and machine learning. In addition to his research activities, he directs the Bioinformatics M.S. graduate program and Co-Directs the Genomics and Bioinformatics Ph.D. program at GW. His focus is on diverse workforce development and supporting institute-wide sustainable bioinformatics innovation infrastructure and solutions for conducting research and development in biomedical sciences. http://orcid.org/0000-0001-8823-9945; https://www.linkedin.com/in/rajamazumder